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The researchers were surprised to find that the concentration of DMT in plasma did not vary between volunteers.
'From previous studies we know DMT is metabolised by the body in a similar way to all other endogenous chemicals, and that it has a low plasma concentration, indicating that it is not particularly bioavailable,' says Dr. Kostian Nergis-Toloba, first author of the study, who is also researcher at the Department phenergan otc uk of Pharmacology.
'The previous studies showed that DMT is metabolised in an unusual way and extreme manner. Therefore, we wanted to investigate if it was possible to use the low plasma concentration of DMT in this study to investigate the pharmacological effects of drugs in vivo.'
DMT or 5MTHF was administered in two different doses, one at a dosage of 300 mg/day and the other 200 mg/day. Both doses were administered on a daily basis for three months and were made up of an active compound and a placebo.
Results indicated that the higher dose resulted in a significant decrease mood, anxiety and aggression. In comparison, the lower dose produced no significant changes.
'The results of this study are very positive and validating,' says Dr Kostian Nergis-Toloba.
'From our previous
phenergan australia over counter studies we know DMT is metabolised by the body in a similar way to all other endogenous chemicals, and that it has a low plasma concentration, indicating that it is not particularly bioavailable. The high plasma concentration of DMT in the present study is a novelty, and may provide insight into the pharmacology of more traditional psychedelic drugs.'
The study was financed by a grant from the Medical Research Council.
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